SUPER CAID
Bromoadiolone
CAS: 28772-56-7
Molecular Formula: C30H23BrO4
SUPER CAID - Names and Identifiers
| Name | Bromoadiolone |
| Synonyms | RATOBAN SUPER CAID SUPER-ROZOL Bromadiolone Bromoadiolone (hydroxy-4coumarinyl3)-3phenyl-3(bromo-4biphenylyl-4)-1propanol-1 1'-biphenyl)-4-yl)3-hydroxy-1-phenylpropyl)-4-hydroxy-2h-1-3-(3-(4'-bromo( 2h-1-benzopyran-2-one,3-(3-(4'-bromo(1,1'-biphenyl)-4-yl)-3-hydroxy-1-phenylp 2h-1-benzopyran-2-one,3-(3-(4`-bromo-(1,1`-biphenyl)-4-yl)-3-hydroxy-1-phenylp (hydroxy-4-coumarinyl-3)-3-phenyl-3-(bromo-4-biphenylyl-4)-1-propanol-1(french 3-[3-(4'-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one 3-[3-(4'-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-2-hydroxy-4H-chromen-4-one |
| CAS | 28772-56-7 |
| EINECS | 249-205-9 |
| InChI | InChI=1/C30H23BrO4/c31-23-16-14-20(15-17-23)19-10-12-22(13-11-19)26(32)18-25(21-6-2-1-3-7-21)28-29(33)24-8-4-5-9-27(24)35-30(28)34/h1-17,25-26,32-33H,18H2 |
SUPER CAID - Physico-chemical Properties
| Molecular Formula | C30H23BrO4 |
| Molar Mass | 527.41 |
| Density | 1.3243 (rough estimate) |
| Melting Point | 200-210° |
| Boling Point | 723.4±60.0 °C(Predicted) |
| Flash Point | 391.282°C |
| Water Solubility | 19 mg l-1 (20 °C) |
| Vapor Presure | 2 x l0-6Pa (20 °C) |
| Appearance | Powder |
| Merck | 13,1366 |
| BRN | 1335336 |
| pKa | 4.04(at 21℃) |
| Storage Condition | -20°C |
| Refractive Index | 1.4490 (estimate) |
| Physical and Chemical Properties | The original drug was yellow powder. m. P. 200-210 °c, vapor pressure 1.78 x 10-5PA (70 °c). 20 C solubility: dimethyl amide 730g/L, ethyl acetate 25g/L, ethanol 8.2g/L, Water 19mg/L. Stable under normal conditions. |
| Use | Used for urban and rural, residential, hotel, restaurant, warehouse, field and other environmental rodent control |
SUPER CAID - Risk and Safety
| Risk Codes | R27/28 - R50 - Very Toxic to aquatic organisms |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | GN4934700 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand) |
SUPER CAID - Upstream Downstream Industry
| Raw Materials | 4-Hydroxycoumarin Benzaldehyde 4-Bromobiphenyl Biphenyl Potassium borohydride Coumarin Bromine Ethylene glycol Acetyl Chloride |
SUPER CAID - Nature
Open Data Verified Data
The original drug was yellow powder. The melting point is 200-210 °c and the vapor pressure (70 °c) is 1.78 x 10-5Pa. 20~25 ° C solubility:(g/L): dimethylamide 730.0, ethyl acetate 25.0, acetone 22.3, chloroform 10.1, ethanol 8.2, methanol 5.6, hexane 0.2, water 0. 019.
Last Update：2024-01-02 23:10:35
SUPER CAID - Preparation Method
Open Data Verified Data
after mixing the quantitative bromobiphenyl, catalyst and solvent, acetic anhydride is added dropwise at a certain temperature, heated to reflux for several hours, and the solvent is distilled off, the residue is transferred to a hydrolysis flask containing an acid solution and subjected to hydrolysis to obtain acetyl-p-bromobiphenyl. 3-{ 2-[P-(p-bromophenyl) benzoylmethyl] benzyl) was prepared from the product obtained by condensation of the product with benzaldehyde and the like and then reacted with 4-hydroxycoumarin. A 4 hydroxy coumarin. Finally, the compound, the reducing agent and the solvent are put into the reaction bottle, stirred, heated, and reacted with isopropyl alcohol, hydrolyzed, filtered, washed and dried to obtain the crude product, and then acidified to obtain bromadiolone.
Last Update：2022-01-01 10:13:28
SUPER CAID - Use
Open Data Verified Data
The second generation anticoagulant rodenticide, good palatability, strong toxicity, high efficiency and broad spectrum, safety. It is effective in rodents that develop resistance to first-generation anticoagulants. For the control of domestic and wild rodents.
Last Update：2022-01-01 10:13:28
SUPER CAID - Safety
Open Data Verified Data
oral LD50 of rats and mice: 1. 125mg/kg, 1.75mg/kg. No obvious irritation to the skin. It is irritating to eyes. Fish LC50 3mg/L(48h), Daphnia LC50 8. 8mg/L, wild duck LD50 lOOOmg/kg, quail LD50 1690mg/kg.
Last Update：2022-01-01 10:13:29
SUPER CAID - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | the original drug has acute oral LD501.75 mg/kg for male rats, 1.125 mg/kg for female and 1.0 mg/kg for rabbits. Acute percutaneous LD509.4 mg/kg in rabbits; Acute inhalation LC50200mg/m3. It has no obvious irritation to the skin and irritation to the eyes. Catfish LC503mg/L (48h), Daphnia LC508.8mg/L. Wild duck LD501000mg/kg, quail LD501690mg/kg. |
| use | the second generation anticoagulant rodenticide is effective for mice with good palatability, strong toxicity and resistance to the first generation anticoagulant. Used to control domestic and wild rodents. 0.005% poison bait can be prepared with 0.25% emulsifiable concentrate, and the bait is rice, wheat, etc. Prevention and control of mice 5~15g of poison bait per room, 2~3g per pile; Prevention and control of wild rats, according to the rat hole, the dosage should be appropriately increased. After animals ingest poisoned dead rats, they will cause 2 poisoning, so poisoned dead rats should be buried deep. used in urban and rural areas, residential buildings, hotels, restaurants, warehouses, wild and other environments to kill rodents used to kill rodents bromadiolone is a new and efficient second generation anticoagulant rodenticide, with strong virulence, high efficiency, broad spectrum, safety, does not cause the characteristics of the second poisoning. The acute virulence to Mus musculus is 44 times that of sodium, 214 times that of murmus, and 88 times that of murmus. It has an ideal killing effect in killing more than 20 kinds of wild mice in grasslands, farmland, forest areas, urban and rural environments, which are resistant to the first generation of anticoagulants in time. |
| production method | is carried out in four steps. (1) Preparation of acetyl-p-brominated biphenyl (referred to as the first step intermediate). (2) Preparation of styrene-p-(4 '-bromophenyl) benzophenone (referred to as the second step intermediate). (3) Preparation of 3-[2-[p-(p-bromophenyl) benzoylmethyl] benzyl]-4-hydroxycoumarin (referred to as the third step intermediate). (4) Preparation of bromine enemies. Raw material consumption quota: p-brominated biphenyl 1100kg/t, acetic anhydride 650kg/t, benzaldehyde 500kg/t, 4-hydroxycoumarin 700kg/t. Preparation of acetyl-to-brominated biphenyls After mixing quantitative brominated biphenyls, catalysts and solvents, acetic anhydride is added dropwise at a certain temperature, heated and refluxed for several hours, the solvent is distilled, the residue is transferred into a hydrolysis bottle containing acid liquid, decomposed, filtered, washed to neutral, the filter cake is vacuum dried to obtain crude products, and then treated to obtain acetyl-to-brominated biphenyls with a content of> 98%. Preparation of styrene-based p (4 '-bromophenyl) benzophenone Add a certain amount of the previous reaction product to the reaction bottle, add solvent, benzaldehyde, and condensing agent, react at a certain temperature, and stand after the reaction, Cool, filter, dry, and crush to obtain crude products. The content is 94%. Preparation of 3-{2-[p-(p-bromophenyl) benzoylmethyl] benzyl}-4-hydroxycoumarin is sequentially added to the previous product, 4-hydroxycoumarin (see the preparation of sultrol), Solvent, catalyst in the reaction bottle, stir and heat up for a certain period of time. Then add solvent, cool crystallization, filter, dry and crush to obtain crude products. The content is 94.5%. Synthesis of bromadiolone The reaction product, reducing agent and two solvents are put into the reaction bottle, stirred and heated, isopropanol is added, and then stirred for a certain period of time. The reaction material is transferred into a hydrolysis bottle containing acid liquid for hydrolysis, filtered, washed and dried to obtain a crude product, and then treated with acidification to obtain bromadiolone with a 95% content. |
| category | pesticide |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 0.49 mg/kg; Oral-mouse LD50: 1.75 mg/kg |
| flammability hazard characteristics | thermal decomposition of toxic bromide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | sand, dry powder, foam |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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